Publications

Argueta, C. E., Figy, C., Bouali, S., Guo, A., Yeung, K. C. & Fenteany, G. RKIP localizes to the nucleus through a bipartite nuclear localization signal and interaction with importin α to regulate mitotic progression. J Biol. Chem. 299, 103023 (2023).

Bartus, É., Tököli, A., Mag, B., Bajcsi, Á., Kecskeméti, G., Wéber, E., Kele, Z., Fenteany, G. & Martinek, T. A. Light-fueled primitive replication and selection in biomimetic chemical systems. J. Am. Chem. Soc. 145, 13371–13383 (2023).

Sacerdote, A., Dave, P., Inoue, T., Bahtiyar, G., Peynado, H., Navarro, V., Cohen, R., L’Eplattanier, M. & Fenteany, G. Pulmonary arterial hypertension in hyperthyroidism: age, ethnic, and gender disparities. J. Autoimmune Dis. Rheumatol. 11, 1–9 (2023).

Fenteany, G., Sharma, G., Gaur, P., Borics, A., Wéber, E., Kiss, E. & Haracska, L. A series of xanthenes inhibiting Rad6 function and Rad6–Rad18 interaction in the PCNA ubiquitination cascade. iScience 25, 4 (2022).

Gaur, P., Fenteany, G. & Tyagi, C. Mode of inhibitory binding of epigallocatechin gallate to the ubiquitin-activating enzyme Uba1. RSC Adv. 11, 8264–8276 (2021).

Fenteany, G., Gaur, P., Sharma, G., Pintér, L., Kiss, E. & Haracska, L. Robust high-throughput assays to assess discrete steps in ubiquitination and related cascades. BMC Mol. Cell Biol. 21, 21 (2020).

Fenteany, G., Gaur, P., Hegedűs, L., Dudás, K., Kiss, E., Wéber, E., Hackler, L., Martinek, T., Puskás, L. G. & Haracska, L. Multilevel structure–activity profiling reveals multiple green tea compound families that each modulate ubiquitin-activating enzyme and ubiquitination by a distinct mechanism. Sci. Rep. 9, 12801 (2019).

Fenteany, G., Inoue, T., Bahtiyar, G. & Sacerdote, A. S. Association of vitamin D repletion with normalization of elevated serum 17-OH-progesterone. Med. Case Rep. 3, 22 (2017).

Powell, D., Inoue, T., Bahtiyar, G., Fenteany, G. & Sacerdote, A. Treatment of nonclassic 11-hydroxylase deficiency with Ashwagandha root. Case Rep. Endocrinol. 2017, 1869560 (2017).

Eddy, N. A. & Fenteany, G. Model studies directed to the synthesis of cucurbitacin I C/D rings. Tetrahedron Lett. 56, 5079–5081 (2015).

Magpusao, A. N., Omolloh, G., Johnson, J., Gascón, J., Peczuh, M. W. & Fenteany, G. Cardiac glycoside activities link Na+/K+ ATPase ion-transport to breast cancer cell migration via correlative SAR. ACS Chem. Biol. 10, 561–569 (2015).

Eddy, N. A., Richardson, J. J. & Fenteany, G. The effect of Lewis acids on the cycloaddition of 3,3,6-trimethylcyclohex-5-ene-1,2,4-trione: Hydrogen transfer versus cycloaddition with cyclopentadiene. Eur. J. Org. Chem. 2013, 5041–5044 (2013).

Clark, A. G., Sider, J. R., Verbrugghe, K., Fenteany, G., von Dassow, G. & Bement, W. M. Identification of small molecule inhibitors of cytokinesis and single cell wound repair. Cytoskeleton 69, 1010–1020 (2012).

Eddy, N. A., Kelly, C. B., Mercadante, M. A., Leadbeater, N. E. & Fenteany, G. Access to dienophilic ene-triketone synthons by oxidation of diketones with an oxoammonium salt. Org. Lett. 14, 498–501 (2012).

Ren, G., Baritaki, S., Marathe, H., Feng, J., Park, S., Beach, S., Bazeley, P. S., Beshir, A. B., Fenteany, G., Mehra, R., Daignault, S., Al-Mulla, F., Keller, E., Bonavida, B., De La Serna, I. & Yeung, K. C. Polycomb protein EZH2 regulates tumor invasion via the transcriptional repression of the metastasis suppressor RKIP in breast and prostate cancer. Cancer Res. 72, 3091–3104 (2012).

Rudnitskaya, A. N., Eddy, N. A., Fenteany, G. & Gascón, J. A. Recognition and reactivity in the binding between Raf kinase inhibitor protein and its small-molecule inhibitor locostatin. J. Phys. Chem. B 116, 10176–10181 (2012).

Beshir, A. B., Argueta, C. E., Menikarachchi, L. C., Gascón, J. A. & Fenteany, G. Locostatin disrupts association of Raf kinase inhibitor protein with binding proteins by modifying a conserved histidine residue in the ligand-binding pocket. For. Immunopathol. Dis. Ther. 2, 47–58 (2011).

Eddy, N. A., Morse, P. D., Morton, M. D. & Fenteany, G. Synthesis of oxazolidinone and tosyl enamines by tertiary amine catalysis. Synlett 5, 699–701 (2011).

Wang, Z., Castellano, S., Kinderman, S. S., Argueta, C. E., Beshir, A. B., Fenteany, G. & Kwon, O. Diversity through a branched reaction pathway: Generation of a library of sixteen multicyclic scaffolds and identification of antimigratory agents. Chem. Eur. J. 17, 649–654 (2011).

Beshir, A. B., Ren, G., Magpusao, A. N., Barone, L. M., Yeung, K. C. & Fenteany, G. Raf kinase inhibitor protein suppresses nuclear factor-κB-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression. Cancer Lett. 299, 137–149 (2010).

Kahsai, A. W., Zhu, S. & Fenteany, G. G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells. Biochim. Biophys. Acta Mol. Cell Res. 1803, 300–310 (2010).

Knecht, D. A., LaFleur, R. A., Kahsai, A. W., Argueta, C. E., Beshir, A. B. & Fenteany, G. Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics. PLoS One 5, e14039 (2010).

Magpusao, A. N., Desmond, R. T., Billings, K. J., Fenteany, G. & Peczuh, M. W. Synthesis and evaluation of antimigratory and antiproliferative activities of lipid-linked [13]-macro-dilactones. Bioorg. Med. Chem. Lett. 20, 5472–5476 (2010).

Ménoret, A., McAleer, J. P., Ngoi, S.-M., Ray, S., Eddy, N. A., Fenteany, G., Lee, S.-J., Rossi, R. J., Mukherji, B., Allen, D. L., Chakraborty, N. G. & Vella, A. T. The oxazolidinone derivative locostatin induces cytokine appeasement. J. Immunol. 183, 7489–7496 (2009).

Beshir, A. B., Guchhait, S. K., Gascón, J. A. & Fenteany, G. Synthesis and structure-activity relationships of metal-ligand complexes that potently inhibit cell migration. Bioorg. Med. Chem. Lett. 18, 498–504 (2008).

Kahsai, A. W., Cui, J., Kaniskan, H. Ü., Garner, P. P. & Fenteany, G. Analogs of tetrahydroisoquinoline natural products that inhibit cell migration and target galectin-3 outside of its carbohydrate-binding site. J. Biol. Chem. 283, 24534–24545 (2008).

Mc Henry, K. T., Montesano, R., Zhu, S., Beshir, A. B., Tang, H. H., Yeung, K. C. & Fenteany, G. Raf kinase inhibitor protein positively regulates cell–substratum adhesion while negatively regulating cell–cell adhesion. J. Cell. Biochem. 103, 972–985 (2008).

Farooqui, R., Zhu, S. & Fenteany, G. Glycogen synthase kinase-3 acts upstream of ADP-ribosylation factor 6 and Rac1 to regulate epithelial cell migration. Exp. Cell Res. 312, 1514–1525 (2006).

Kahsai, A. W., Zhu, S., Wardrop, D. J., Lane, W. S. & Fenteany, G. Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin, disrupting interactions of radixin with actin and CD44. Chem. Biol. 13, 973–983 (2006).

Stossel, T. P., Fenteany, G. & Hartwig, J. H. Cell surface actin remodeling. J. Cell. Sci. 119, 3261–3264 (2006).

Farooqui, R. & Fenteany, G. Multiple rows of cells behind an epithelial wound edge extend cryptic lamellipodia to collectively drive cell-sheet movement. J. Cell Sci. 118, 51–63 (2005).

Zhu, S., McHenry, K. T., Lane, W. S., Fenteany, G., Mc Henry, K. T., Lane, W. S. & Fenteany, G. A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration. Chem. Biol. 12, 981–991 (2005).

Altan, Z. M. & Fenteany, G. c-Jun N-terminal kinase regulates lamellipodial protrusion and cell sheet migration during epithelial wound closure by a gene expression-independent mechanism. Biochem. Biophys. Res. Commun. 322, 56–67 (2004).

Fenteany, G. & Glogauer, M. Cytoskeletal remodeling in leukocyte function. Curr. Opin. Hematol. 11, 15–24 (2004).

Ankala, S. V & Fenteany, G. Aryl, alkyl bis-silyl ethers: Rapid access to monoprotected aryl alkyl and biaryl ethers. Synlett 6, 825–828 (2003).

Fenteany, G. & Zhu, S. Small-molecule inhibitors of actin dynamics and cell motility. Curr. Top. Med. Chem. 3, 593–616 (2003).

Ankala, S. V & Fenteany, G. Selective deprotection of either alkyl or aryl silyl ethers from aryl, alkyl bis-silyl ethers. Tetrahedron Lett. 43, 4729–4732 (2002).

Mc Henry, K. T., Ankala, S. V, Ghosh, A. K. & Fenteany, G. A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration. ChemBioChem 3, 1105–1111 (2002).

Fenteany, G., Janmey, P. A. & Stossel, T. P. Signaling pathways and cell mechanics involved in wound closure by epithelial cell sheets. Curr. Biol. 10, 831–838 (2000).

Corey, E. J., Li, W. D. Z., Nagamitsu, T. & Fenteany, G. The structural requirements for inhibition of proteasome function by the lactacystin-derived β-lactone and synthetic analogs. Tetrahedron 55, 3305–3316 (1999).

Fenteany, G. & Schreiber, S. L. Lactacystin, proteasome function, and cell fate. J. Biol. Chem. 273, 8545–8548 (1998).

Craiu, A., Gaczynska, M., Akopian, T., Gramm, C. F., Fenteany, G., Goldberg, A. L. & Rock, K. L. Lactacystin and clasto-lactacystin β-lactone modify multiple proteasome β-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation. J. Biol. Chem. 272, 13437–13445 (1997).

Degnan, B. M., Degnan, S. M., Fenteany, G. & Morse, D. E. A Mox homeobox gene in the gastropod mollusc Haliotis rufescens is differentially expressed during larval morphogenesis and metamorphosis. FEBS Lett.411, 119–122 (1997).

Fenteany, G. & Schreiber, S. L. Specific inhibition of the chymotrypsin-like activity of the proteasome induces a bipolar morphology in neuroblastoma cells. Chem. Biol. 3, 905–912 (1996).

Fenteany, G., Standaert, R. F., Lane, W. S., Choi, S., Corey, E. J. & Schreiber, S. L. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science. 268, 726–731 (1995).

Fenteany, G., Standaert, R. F., Reichard, G. A., Corey, E. J. & Schreiber, S. L. A β-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proc. Natl. Acad. Sci. USA 91, 3358–3362 (1994).

Fenteany, G. & Morse, D. E. Specific inhibitors of protein synthesis do not block RNA synthesis or settlement of planktonic larvae in a marine gastropod mollusc (Haliotis rufescens). Biol. Bull. 184, 6–14 (1993).